Provided customers follow recommended use and there are no other substantial dietary or supplement sources of vitamins or minerals, healthy individuals may combine any of our products without a risk of excessive vitamin or mineral intake. When formulating the products, safety, including avoidance of vitamin and mineral toxicity, is our priority. Most vitamins and minerals have a tolerable upper intake level (UL) established by the United States National Academy of Sciences. Consuming any more than this does increase risk of negative effects; however, the amounts of vitamins and minerals were carefully considered when developing products by PURE.